Patients with C difficile infection should discontinue use of implicated agents when possible and avoid antiperistaltic agents and narcotics (Management Guidelines)[Leffler 2009]
The Society for Healthcare Epidemiology of America/Infectious Diseases Society of America guidelines recommend oral metronidazole as the preferred treatment and oral vancomycin as an alternative agent or for more severe disease (Management Guidelines)[Cohen 2010]
Recommended treatment for relapse is to repeat standard treatment, sometimes followed by a taper with 125 mg orally every other day for ≥ 6 weeks
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