Overview of HIV Prevention

  • Author: Sharon L. Hillier, PhD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 8/24/18 (What's New)

Summary

  • A series of HIV vaccine trials testing recombinant vaccine candidates has been unsuccessful[Flynn 2005; Pitisuttithum 2006; Buchbinder 2008]
  • RV144, a candidate vaccine using a prime-boost vaccine strategy, demonstrated modest efficacy in a randomized trial[Rerks-Ngarm 2009]
  • VRC01 vaccine slightly delayed viral round in virologically suppressed patients discontinuing ART, but viral suppression was not maintained at 8 weeks in 2 phase I trials[Bar 2016]

Action required