Management of AIDS-Defining Cancers
Summary
- PIs may worsen chemotherapy-related myelotoxicity[Bower 2004]
- Zidovudine can be associated with myelotoxicity and should be avoided during chemotherapy[Beumer 2014; Kaplan 2012; Rudek 2011]
- Pharmacologic boosters, ritonavir and cobicistat, are CYP3A4 inhibitors with reported and anticipated interactions with many chemotherapy agents as well as some targeted antitumor drugs[Alvarnas 2017; Berretta 2016; Rubinstein 2014; Beumer 2014]
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Keywords: Cancer