Management of IRIS
Summary
- Prevalence of IRIS
- Estimated prevalence of IRIS in asymptomatic patients initiating ART is between 3% to 38% (Table 1)[Ratnam 2006; French 2000; Jevtović 2005; Murdoch 2008; Orikiiriza 2010; Fischl 2010] and between 8% to 54% in symptomatic patients (Table 2)[Breton 2004; Lortholary 2005; Shelburne 2005; Bicanic 2009; Zolopa 2009; Narendran 2013]
- IRIS rates vary with the degree of immunosuppression before ART initiation and the burden of OIs in the local population
- TB IRIS is among the most common presentations of paradoxical IRIS[Breton 2004; Shelburne 2005; Abdool Karim 2010; Havlir 2011; Blanc 2011; Naidoo 2012; Haddow 2012]
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Keywords: IRIS, Resource-Limited Settings