Key Principles and Recommended Regimens for First-line Antiretroviral Therapy
Summary
- Emtricitabine/tenofovir AF is a recommended first-line NRTI pair in US and European guidelines[DHHS ART; IAS-USA ART; EACS ART]
- Cobicistat/elvitegravir/emtricitabine/tenofovir AF and cobicistat/elvitegravir/emtricitabine/tenofovir DF are recommended by the DHHS, EACS, and IAS-USA guidelines as alternative first-line HIV regimens[DHHS ART; EACS ART; IAS-USA ART]
- In 2 phase III randomized clinical trials in treatment-naive patients, cobicistat/elvitegravir/emtricitabine/tenofovir AF was associated with noninferior Week 48 virologic efficacy, smaller increases in serum creatinine, less proteinuria, and smaller decreases in lower spine and hip bone mineral density vs cobicistat/elvitegravir/emtricitabine/tenofovir DF[Sax 2015]
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