Clinical Implications of HIV Pathogenesis
Summary
- Viral replication and an inflammatory host response induce destruction of CD4+ cells early in acute HIV infection
- Significant loss of CD4+ cells occurs in the gut-associated lymphoid tissue of the gastrointestinal tract, associated with an increased permeability of the mucosa to gut microbial flora[Veazey 2001; Guadalupe 2003; Mehandru 2004; Brenchley 2004; Brenchley 2006]
- Activation of CD4+ cells increases dramatically during acute HIV infection[Deeks 2004; Douek 2009]
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Keywords: Acute HIV Infection