Management of Neurologic Diseases

  • Authors: David M. Simpson, MD; Jessica Robinson-Papp, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/1/16 (What's New)


  • PML is the most common infiltrative brain lesion observed in patients with AIDS and is caused by the JC virus
    • PML causes slowly progressive focal neurologic deficits
    • Brain lesions are present on MRI, usually appearing as a T2 signal abnormality in the white matter without mass effect or contrast enhancement (Figure 2)[Whiteman 1993]

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