Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care

  • Authors: Amanda H. Corbett, PharmD, BCPS, FCCP; Colin I. Sheffield, PharmD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 6/3/19 (What's New)

Summary

  • Significant drug–drug interactions complicate concomitant treatment of HIV infection and TB
  • Cotreatment of HIV and TB requires careful consideration of potential drug interactions and the need for patient monitoring (Table 8)
    • Rifampin and Antiretrovirals
    • Efavirenz-based ART is the recommended option for patients receiving rifampin-based TB regimen
    Rifabutin and Antiretrovirals
      Rifapentine and Antiretrovirals
        Other Antimycobacterial Agents and Antiretrovirals

        Action required

        Keywords: Drug-Drug Interactions, Pharmacokinetics, Tuberculosis

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