Special Considerations Related to Aging in HIV-Infected Patients
Summary
- Chronic immune activation contributes to immunologic compromise in HIV-infected patients and uninfected aging individuals, although mechanisms differ[Effros 2008; Appay 2008; Jiang 2009]
- Net result is likely to contribute to accelerated loss of immune function in older, HIV-infected patients[Effros 2008; Appay 2008; Brenchley 2006; Effros 2011]
- Immunologic perturbations seen in HIV-uninfected older individuals and HIV-infected patients include: reduced thymic volume and function, inversion of the normal CD4+/CD8+ cell count ratio, reduced numbers of naive and increased numbers of memory CD4+ and CD8+ cells, shortened telomeres in CD4+ and CD8+ cells, and loss of CD28 expression on CD8+ cells[Effros 2011; High 2012; Effros 2008; Jamieson 1999; Kalayjian 2003; Lichterfeld 2008]
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Keywords: HIV and Older Patients