Special Considerations Related to Aging in Persons With HIV

  • Author: Matthew B. Goetz, MD (More Info)
  • Section Editor: Judith S. Currier, MD, MSc
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 11/1/21 (What's New)


  • Chronic immune activation contributes to immunologic compromise in patients with HIV and uninfected aging individuals, although mechanisms differ[Effros 2008; Appay 2008; Jiang 2009]
  • Immunologic perturbations seen in older individuals both with and without HIV include: reduced thymic volume and function, inversion of the normal CD4+/CD8+ cell count ratio, reduced numbers of naive and increased numbers of memory CD4+ and CD8+ cells, shortened telomeres in CD4+ and CD8+ cells, and loss of CD28 expression on CD8+ cells[Effros 2011; High 2012; Effros 2008; Jamieson 1999; Kalayjian 2003; Lichterfeld 2008]

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