Agents Used in Antiretroviral Therapy

  • Authors: Philip Grant, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 7/19/21 (What's New)


  • Attachment inhibitors bind to gp120 and selectively inhibit the interaction between the virus and cellular CD4 receptors, which prevents viral entry into host cells
  • Fostemsavir is currently the only approved agent in this class[FDA Fostemsavir]
  • Fostemsavir
    • Fostemsavir was approved in July 2020 for use in combination with other ARV agents in heavily treatment–experienced patients with multidrug-resistant HIV infection who are experiencing failure of their current ART regimen[FDA Fostemsavir]

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