Timing of Initiation of First-line Antiretroviral Therapy

  • Authors: Marshall J. Glesby, MD, PhD; Timothy J. Wilkin, MD, MPH (More Info)
  • Section Editor: Joel E. Gallant, MD, MPH
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/1/16 (What's New)


  • When confronted with decisions regarding antiretroviral therapy initiation in patients newly diagnosed with HIV infection, primary care physicians should determine the need for expert consultation or patient referral based on:
    • Their level of experience in managing patients receiving antiretroviral therapy
    • Individual patient factors, including patient readiness to start therapy, the presence of comorbidities that may affect the optimal timing of treatment initiation, and the patient’s risk of transmitting HIV infection to others

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