Timing of Initiation of First-line Antiretroviral Therapy

  • Authors: Marshall J. Glesby, MD, PhD; Timothy J. Wilkin, MD, MPH (More Info)
  • Section Editor: Joel E. Gallant, MD, MPH
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/1/16 (What's New)


  • Several cohort studies have demonstrated that the risk for certain AIDS- and non-AIDS-related cancers is greater in patients with CD4+ cell counts < 350 cells/mm3[Marin 2009; Guiguet 2009; Monforte 2008; Bruyand 2009]
  • Cancers related to chronic viral infections seem to be particularly associated with immunodeficiency[Silverberg 2009; Grulich 2007]
  • Cumulative HIV viremia may be associated with the risk of non-Hodgkin’s lymphoma and other AIDS-defining cancers, independent of other factors[Zoufaly 2009]

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