Timing of Initiation of First-line Antiretroviral Therapy
Summary
- Several cohort studies have demonstrated that the risk for certain AIDS- and non-AIDS-related cancers is greater in patients with CD4+ cell counts < 350 cells/mm3[Marin 2009; Guiguet 2009; Monforte 2008; Bruyand 2009]
- Cancers related to chronic viral infections seem to be particularly associated with immunodeficiency[Silverberg 2009; Grulich 2007]
- Cumulative HIV viremia may be associated with the risk of non-Hodgkin’s lymphoma and other AIDS-defining cancers, independent of other factors[Zoufaly 2009]
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