Non–AIDS-Defining Cancers

  • Authors: David Aboulafia, MD (More Info)
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 11/15/21 (What's New)


  • Current NCCN guidelines emphasize importance of smoking as risk factor for anal carcinoma with risk increased ~ 8 times for smokers versus nonsmokers [guideline:  NCCN HIV Cancer][NCCN Anal]
  • 9-valent human papillomavirus vaccine indicated for prevention of anal cancer and associated precancerous lesions due to HPV types 6, 11, 16, and 18, 31, 33, 45, 52, and 58 in people 9 through 45 years of age
  • AIN may be treated with topical agents and/or ablative therapy,[Abbasakoor 2005; Stier 2013] including infrared coagulation

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