Tuberculosis and Other Mycobacterial Infections

  • Authors: Richard E. Chaisson, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 3/30/17 (What's New)

Summary

  • Diagnosis of TB in children is based on history of exposure, epidemiologic risk factors, clinical presentation, chest radiograph, results of tuberculin skin testing or QuantiFERON TB Gold In-Tube interferon-γ release assay (for children older than 2 years of age), and results of Xpert MTB/RIF tests or mycobacterial cultures from respiratory secretions, gastric aspirates, stool, cerebrospinal fluid, and/or blood[Cruz 2007; Starke 2004; Chisti 2014; WHO Xpert; WHO Surveillance 2015]
  • Chest radiographs in children with pulmonary TB commonly show intrathoracic lymphadenopathy with or without parenchymal disease[Starke 1989; Leung 1992]

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