inPractice® - Benzodiazepines

Authors: Amanda H. Corbett, PharmD, BCPS, FCCP; Colin I. Sheffield, PharmD (More Info)
Section Editor: Eric S. Daar, MD
Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
Last Reviewed: 6/1/18 (What's New)

Efavirenz, nevirapine, and etravirine decrease concentrations of certain benzodiazepines, whereas PIs, cobicistat/elvitegravir/emtricitabine/tenofovir DF, and cobicistat/elvitegravir/emtricitabine/tenofovir AF typically increase concentrations (Table 10)^{[DHHS ART; FDA COBI/EVG/TDF/FTC; FDA COBI/EVG/TAF/FTC]}
Lorazepam, oxazepam, and temazepam are not metabolized by CYP 450 3A4 and do not interact with antiretrovirals
Use of single-dose IV midazolam is acceptable for patients receiving PIs if they are being monitored, such as during a medical procedure; otherwise, do not coadminister^{[DHHS ART]}