Timing of Initiation of First-line Antiretroviral Therapy

  • Authors: Marshall J. Glesby, MD, PhD; Timothy J. Wilkin, MD, MPH (More Info)
  • Section Editor: Joel E. Gallant, MD, MPH
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/1/16 (What's New)


  • Liver-related deaths were inversely associated with CD4+ cell counts in the D:A:D cohort study[Weber 2006]
    • Risk of liver-related death was significantly lower among patients with a recent CD4+ cell count ≥ 500 cells/mm3 vs CD4+ cell count of 350-499 cells/mm3
  • Both the US guidelines (Management Guidelines)[DHHS ART] and the British guidelines (Management Guidelines)[BHIVA ART] advise that HBV or HCV coinfection may be an indication for earlier ART initiation in some patients

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