Timing of Initiation of First-line Antiretroviral Therapy
Summary
- Liver-related deaths were inversely associated with CD4+ cell counts in the D:A:D cohort study[Weber 2006]
- Risk of liver-related death was significantly lower among patients with a recent CD4+ cell count ≥ 500 cells/mm3 vs CD4+ cell count of 350-499 cells/mm3
- Both the US guidelines (Management Guidelines)[DHHS ART] and the British guidelines (Management Guidelines)[BHIVA ART] advise that HBV or HCV coinfection may be an indication for earlier ART initiation in some patients
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