Key Principles and Recommended Regimens for First-line Antiretroviral Therapy

  • Author: Paul E. Sax, MD (More Info)
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 11/12/21 (What's New)

Considerations for Choosing a First-line NNRTI

When choosing among efavirenz, doravirine, and rilpivirine, the latter would be a reasonable option in patients with baseline HIV-1 RNA < 100,000 copies/mL and CD4+ cell count > 200 cells/mm³, where the better tolerability of rilpivirine is not offset by excess risk of virologic failure. Additional considerations for the use of rilpivirine...