Special Considerations and Clinical Management of HIV in Patients With Substance Use Disorder
Summary
- Nevirapine and efavirenz reduce methadone levels and precipitate opioid withdrawal (Table 7)[Altice 1999; Clarke 2001]
- Efavirenz significantly reduces buprenorphine levels but is not associated with opioid withdrawal[McCance-Katz 2006a]
- Dosage adjustments are not needed during coadministration of etravirine or rilpivirine with either methadone or buprenorphine[Crauwels 2010; Crauwels 2013]
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