Viral Infections

  • Author: Jin S. Suh, MD, FACP; Humberto R. Jimenez, PharmD, BCPS, AAHIVP (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 8/1/21 (What's New)


  • Diagnosis of HSV infection is confirmed only by laboratory testing. HSV DNA detection with PCR assays are the preferred modality, although viral culture remains important to identify acyclovir resistance
  • Serologic testing can be used to diagnose HSV if recurrent genital symptoms are continually negative (PCR/culture), clinical signs of HSV infection with laboratory confirmation, or when a partner has documented HSV. Routine serologic screening for HSV-2 may be considered as a part of HIV management (Management Guidelines)[CDC OI]

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