Management of IRIS

  • Authors: Irini Sereti, MD, MHS; Philip Grant, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 4/1/16 (What's New)


  • IRIS associated with HBV or HCV generally occurs within the first 8 weeks of ART with nonspecific symptoms of fevers, night sweats, nausea, fatigue, and jaundice
  • Liver biopsy typically shows necrotizing inflammation with increased CD8+ T-cell infiltration
  • Microbiologic evaluation for other causes of liver disease is negative[Carr 1997; Zylberberg 1998]

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