Management of IRIS
Summary
- IRIS is categorized as paradoxical IRIS or unmasking IRIS by whether the pathogen involved in the reaction has been diagnosed at the time of ART initiation
- Immune features of paradoxical IRIS include monocyte/macrophage activation and T-cell reconstitution[Grant 2012; Pean 2012; Barber 2010; Barber 2012; Andrade 2013]
- Unmasking IRIS is characterized by cytokine production similar to that seen in patients with active opportunistic infections[Haddow 2009; Porter 2010]
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Keywords: IRIS, Tuberculosis