Optimizing Adherence to Antiretroviral Therapy
Summary
- Psychiatric and substance abuse disorders, particularly untreated depression, are associated with reduced adherence to ART [Malta 2010; Pence 2009; Whetten 2008; Azar 2010; Farley 2010; Kacanek 2015]
- Comorbid illnesses may be associated with lower adherence because of the complexity of managing multiple treatment regimens and adverse effects from drug interactions
- Baseline medical evaluation should consider previously diagnosed and undiagnosed comorbid conditions and the number and frequency of coadministered medications as factors that may influence adherence
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