Optimizing Adherence to Antiretroviral Therapy

  • Author: Nancy Reynolds, PhD, RN, C-NP, FAAN (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 3/21/18 (What's New)


  • Psychiatric and substance abuse disorders, particularly untreated depression, are associated with reduced adherence to ART [Malta 2010; Pence 2009; Whetten 2008; Azar 2010; Farley 2010; Kacanek 2015]
  • Comorbid illnesses may be associated with lower adherence because of the complexity of managing multiple treatment regimens and adverse effects from drug interactions
  • Baseline medical evaluation should consider previously diagnosed and undiagnosed comorbid conditions and the number and frequency of coadministered medications as factors that may influence adherence

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