Modifying Antiretroviral Therapy in Virologically Suppressed HIV-Infected Patients
Summary
- Virologically suppressed patients with a high risk of cardiovascular disease and nephrotoxicity may need to switch to a new regimen that excludes or limits both ritonavir and NRTIs INSTI Plus an NNRTI
- SWORD-1 and SWORD-2 trials demonstrated that switching virologically suppressed patients from various regimens to once-daily oral dolutegravir plus rilpivirine was well tolerated and noninferior to continuing baseline therapy at Week 48[Llibre 2018]
- TANGO study showed comparable virologic efficacy of switching to dolutegravir/lamivudine vs continued tenofovir AF–based 3-drug or 4-drug ART[Ait-Khaled 2019]
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Keywords: Switch Strategies