Agents Used in Antiretroviral Therapy

  • Authors: Philip Grant, MD (More Info)
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 10/1/18 (What's New)

Summary

  • Integrase strand transfer inhibitors (INSTIs) act to inhibit strand transfer, a process catalyzed by HIV integrase enzyme
  • FDA-approved INSTIs include bictegravir, dolutegravir, elvitegravir, and raltegravir (Table 7)
  • INSTI regimens are among preferred regimens in US and European guidelines and are the only preferred regimens in US guidelines
  • Dolutegravir
      Elvitegravir
        Raltegravir
          Bictegravir

          Action required