Modifying Antiretroviral Therapy in Virologically Suppressed HIV-Infected Patients

  • Author: José R. Arribas, MD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Joseph J. Eron, Jr., MD; Daniel R. Kuritzkes, MD
  • Last Reviewed: 10/18/21 (What's New)


  • According to the US Department of Health and Human Services antiretroviral therapy guidelines panel, the fundamental tenet of changing antiretroviral therapy in the setting of virologic suppression is the maintenance of viral suppression without compromise of future treatment options
  • International antiretroviral therapy guidelines outline specific criteria for patients on suppressive antiretroviral therapy to be considered for treatment modification[DHHS ART] (Management Guidelines)[EACS ART] (Management Guidelines)[IAS-USA ART]
    • The DHHS panel has instituted evidence-based categorization of switch strategies for virologically suppressed patients (Table 2) (Management Guidelines)[DHHS ART]

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