Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care

  • Authors: Amanda H. Corbett, PharmD, BCPS, FCCP; Colin I. Sheffield, PharmD (More Info)
  • Section Editor: Eric S. Daar, MD
  • Editors in Chief: Daniel R. Kuritzkes, MD; Joseph J. Eron, Jr., MD
  • Last Reviewed: 6/3/19 (What's New)


  • Coadministration of azole antifungals and antiretrovirals results in significant drug interactions (Table 5)
  • Caution should also be used if administering antiretrovirals with echinocandin antifungals caspofungin and micafungin[FDA Micafungin; FDA Caspofungin]
  • Fluconazole and NNRTIs and PIs
    • Fluconazole has least potential for drug interactions with antiretrovirals of azole antifungals with no significant effect observed or expected in combination with most boosted PIs
      Isavuconazole and NNRTIs and PIs
        Itraconazole and NNRTIs and PIs
          Posaconazole and NNRTIs and PIs
            Voriconazole and NNRTIs and PIs
              Ketoconazole and NNRTIs and PIs
                Azole Antifungals and Other Antiretrovirals

                Action required