Key Pharmacologic Principles and Drug-Drug Interactions in HIV Patient Care
Summary
- Coadministration of azole antifungals and antiretrovirals results in significant drug interactions (Table 5)
- Caution should also be used if administering antiretrovirals with echinocandin antifungals caspofungin and micafungin[FDA Micafungin; FDA Caspofungin] Fluconazole and NNRTIs and PIs
- Fluconazole has least potential for drug interactions with antiretrovirals of azole antifungals with no significant effect observed or expected in combination with most boosted PIs
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Keywords: Drug-Drug Interactions, Pharmacokinetics