Management of Bone Disease and Body Composition Changes
Summary
- Most studies have suggested that the association between the early loss of BMD and the start of ART appears to occur regardless of ARV agent or class[Tebas 2007; Brown 2009; van Vonderen 2009]
- The ANRS 143/NEAT 100 study demonstrated that use of NRTI-containing vs sparing therapy was associated with greater likelihood of BMD loss over 96 weeks
- A bone substudy of ACTG 5142 demonstrated that the initiation of ART was associated with a decrease in total body bone mass of 2% to 4% that was independent of the regimen selected and stabilized by Week 48
Action required
- Login now to access all of your entitled content
or - View additional options to gain access to this content
Keywords: Bone Disease , Treatment Complications