Other Viruses That Affect the Liver

  • Authors: Lisa VanWagner, MD, MSc, FAST (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 9/4/18 (What's New)


  • DV is transmitted to humans by Aedes mosquito bites, causing clinical syndromes ranging from a mild febrile illness to hemorrhagic fever and dengue shock syndrome[Halstead 2007; Lee 2006]
  • In dengue-associated acute hepatitis, elevated aminotransferase levels peak around Day 9 of symptoms, with gradual resolution over 3 weeks. Aspartate aminotransferase elevation is greater than alanine aminotransferase levels[Souza 2004]
  • Liver damage is more frequent in women, patients with sequential DV infection, hemorrhagic cases, and patients infected with DV-3 and DV-4 serotypes[Guilarde 2008]

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