Other Viruses That Affect the Liver

  • Authors: Lisa VanWagner, MD, MSc, FAST (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 9/4/18 (What's New)


  • Disease due to EBV infection is diagnosed by the combination of a compatible clinical syndrome plus positive EBV IgM and/or heterophile antibody tests
  • Heterophile antibody testing (monospot) is highly sensitive and specific in adults with clinical infectious mononucleosis[Luzuriaga 2010]
  • False-positive monospot testing may occur with HIV, other viral infections (eg, rubella, parvovirus), lymphoma, and systemic lupus erythematosus

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