Other Viruses That Affect the Liver

  • Authors: Lisa VanWagner, MD, MSc, FAST (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 9/4/18 (What's New)



  • Viral hepatitis may be caused by a broad range of pathogens (Table 1)
  • Hepatic injury may be mild, with only transient elevation in aminotransferases, or may lead to acute hepatitis or fulminant hepatic failure
  • The effects of these viral infections on immunocompromised hosts, including recipients of solid organ transplantations, deserve special attention

Herpes Viruses and the Liver

  • Infection with members of the family Herpesviridae is frequently associated with hepatitis
    • Important pathogenic Herpesviridae include CMV, EBV, HSV-1, HSV-2, VZV, HHV-6, HHV-7, and HHV-8
  • All herpes viruses share an ability to remain latent within the body over long periods of time and can be reactivated later in life, especially in the setting of immunosuppression

Herpes Viruses: Cytomegalovirus