Nonalcoholic Steatohepatitis: Epidemiology, Screening, Risk Assessment, Diagnosis, and Management

  • Author: Philip N. Newsome, PhD, FRCPE (More Info)
  • Editor In Chief: Quentin M. Anstee, BSc, MB BS, PhD, MRCP(UK), FRCP
  • Last Reviewed: 8/23/19 (What's New)

General Overview and Description of NAFLD

  • NAFLD is caused by excessive hepatic fat accumulation and is closely related to metabolic syndrome[AASLD 2018]
    • To meet the clinical definition of NAFLD, patients must lack secondary drivers of hepatic steatosis such as alcohol consumption, infection with genotype 3 HCV, or monogenic hereditary disorders
  • NAFLD encompasses a spectrum of liver damage caused by fat accumulation, ranging from a more indolent steatosis to decompensated liver cirrhosis
    • Approximately 25% of US adults with NAFLD progress to NASH, a more advanced disease characterized by inflammation, hepatocyte ballooning, and an increased risk of fibrosis and liver-related mortality[Diehl 2017]

Nonalcoholic fatty liver disease (NAFLD) is caused by an excessive accumulation of fat within the liver in the absence of other drivers of hepatic steatosis such as alcohol consumption, infection with genotype 3 HCV, or monogenic hereditary disorders.[AASLD 2018]...

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Keywords: NAFLD