Nonalcoholic Steatohepatitis: Epidemiology, Screening, Risk Assessment, Diagnosis, and Management

  • Author: Philip N. Newsome, PhD, FRCPE (More Info)
  • Editor In Chief: Quentin M. Anstee, BSc, MB BS, PhD, MRCP(UK), FRCP
  • Last Reviewed: 8/23/19 (What's New)


  • NAFLD is caused by excessive hepatic fat accumulation and is closely related to metabolic syndrome[AASLD 2018]
    • To meet the clinical definition of NAFLD, patients must lack secondary drivers of hepatic steatosis such as alcohol consumption, infection with genotype 3 HCV, or monogenic hereditary disorders
  • NAFLD encompasses a spectrum of liver damage caused by fat accumulation, ranging from a more indolent steatosis to decompensated liver cirrhosis

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