Nonalcoholic Steatohepatitis: Epidemiology, Screening, Risk Assessment, Diagnosis, and Management

  • Author: Philip N. Newsome, PhD, FRCPE (More Info)
  • Editor In Chief: Quentin M. Anstee, BSc, MB BS, PhD, MRCP(UK), FRCP
  • Last Reviewed: 8/23/19 (What's New)


  • The most widely studied genetic modifier of NAFLD is the PNPLA3 gene encoding adiponutrin[Diehl 2017]
    • PNPLA3 SNPs have been associated with an increased risk for higher liver fat content, increased prevalence and severity of NASH, and a greater risk of hepatocellular carcinoma[Sookoian 2011; Liu 2014a]
  • Other genetic factors strongly associated with NAFLD include SNPs in TM6SF2, KLF6, PPARα, PPARγ, and HSD17B13[Diehl 2017; Miele 2008; Liu 2014b; Abul-Husn 2018]

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