Nonalcoholic Steatohepatitis: Epidemiology, Screening, Risk Assessment, Diagnosis, and Management

  • Author: Philip N. Newsome, PhD, FRCPE (More Info)
  • Editor In Chief: Quentin M. Anstee, BSc, MB BS, PhD, MRCP(UK), FRCP
  • Last Reviewed: 8/23/19 (What's New)


  • The management of patients with NAFLD principally involves lifestyle interventions aimed at sustained weight loss
    • EASL recommends that patients with NAFLD who are overweight or obese should aim for a weight loss of 7% to 10%[EASL 2016]
    • A large study evaluating a 12-month program of combined calorie reduction and exercise in patients with NASH reported marked improvement in liver histology associated with weight loss, with the greatest benefits (ie, resolution of NASH) in those who achieved ≥ 10% weight loss[Vilar-Gomez 2015]

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