NAFLD is caused by excessive hepatic fat accumulation and is closely related to metabolic syndrome[AASLD 2018]
To meet the clinical definition of NAFLD, patients must lack secondary drivers of hepatic steatosis such as alcohol consumption, infection with genotype 3 HCV, or monogenic hereditary disorders
NAFLD encompasses a spectrum of liver damage caused by fat accumulation, ranging from a more indolent steatosis to decompensated liver cirrhosis
Approximately 25% of US adults with NAFLD progress to NASH, a more advanced disease characterized by inflammation, hepatocyte ballooning, and an increased risk of fibrosis and liver-related mortality[Diehl 2017]
Precise data are limited on the prevalence of NAFLD and NASH due to varying methods for diagnosis and lack of routine record keeping
Determining NASH prevalence is challenged by the need for diagnostic biopsy
The estimated global prevalence of NAFLD is 25.24%, with rates varying among different regions...
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