Virology and Immunology of Hepatitis Viruses

  • Authors: Esperance Anne Kreek Schaefer, MD, MPH; Raymond T. Chung, MD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/10/18 (What's New)


  • HBV is a small, enveloped, hepatotropic DNA virus that belongs to the Hepadnaviridae family
  • The Dane particle is the infectious particle of the HBV, containing a nucleocapsid surrounded by a lipid envelope with 3 surface antigens (Figure 2)
  • Inside the cytoplasm, the nucleocapsid is transported to the nucleus and the viral DNA is repaired to create a fully double-stranded cccDNA

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