Virology and Immunology of Hepatitis Viruses

  • Authors: Esperance Anne Kreek Schaefer, MD, MPH; Raymond T. Chung, MD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/10/18 (What's New)


  • HAV is an RNA virus belonging to the Picornaviridae family and travels as an icosahedral, nonenveloped particle (Figure 6)
  • 6 genotypes of HAV have been described to date, 3 of which are known to infect humans[Cristina 2007]
  • HAV arrives at the liver from the gut by portal circulation and gains access to hepatocytes at the sinusoids, where it sheds its capsid and the viral genome is released into cytoplasm

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