Virology and Immunology of Hepatitis Viruses

  • Authors: Esperance Anne Kreek Schaefer, MD, MPH; Raymond T. Chung, MD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/10/18 (What's New)


  • 4 genotypes of HEV have been identified, with distinct geographic distribution and clinical associations
    • Genotypes 1 and 2 are associated with areas of high endemicity and account for epidemic outbreaks associated with flooding and water contamination by human waste
    • Genotypes 3 and 4 are generally observed in areas of low endemicity, are associated with sporadic cases and less-severe disease, and infection may not show overt symptoms of hepatitis[Renou 2011]

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