Hepatitis A Virus and Hepatitis E Virus: Different Viruses With Similar Stories
- Both HAV and HEV are highly prevalent viruses that primarily replicate in the liver and cause acute hepatic injury
- Both viruses appear to be important cofactors in the morbidity and mortality associated with other chronic liver diseases
- Although members of different virus families, similarities in epidemiology, modes of transmission, and clinical presentation make it helpful to consider them together
- Hepatitis E, in particular, is underrecognized as a pathogen, and detection and prevention are constrained by limited awareness by clinicians
Both hepatitis A virus (HAV) and hepatitis E virus (HEV) are highly prevalent viruses that primarily replicate in the liver and cause acute hepatic injury. Hepatitis A was originally designated as “infectious hepatitis” to distinguish it from “serum hepatitis,” which is now attributed to hepatitis B.[Krugman 1967]...