Introduction

• Both HAV and HEV are highly prevalent viruses that primarily replicate in the liver and cause acute hepatic injury
  • Both viruses appear to be important cofactors in the morbidity and mortality associated with other chronic liver diseases
• Although members of different virus families, similarities in epidemiology, modes of transmission, and clinical presentation make it helpful to consider them together
• Hepatitis E, in particular, is underrecognized as a pathogen, and detection and prevention are constrained by limited awareness by clinicians

Both hepatitis A virus (HAV) and hepatitis E virus (HEV) are highly prevalent viruses that primarily replicate in the liver and cause acute hepatic injury. Hepatitis A was originally designated as “infectious hepatitis” to distinguish it from “serum hepatitis,” which is now attributed to hepatitis B.^{[Krugman 1967]...}