Hepatitis A Virus and Hepatitis E Virus: Different Viruses With Similar Stories

  • Author: Kenneth E. Sherman, MD, PhD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 5/17/18 (What's New)

Introduction

  • Both HAV and HEV are highly prevalent viruses that primarily replicate in the liver and cause acute hepatic injury
    • Both viruses appear to be important cofactors in the morbidity and mortality associated with other chronic liver diseases
  • Although members of different virus families, similarities in epidemiology, modes of transmission, and clinical presentation make it helpful to consider them together
  • Hepatitis E, in particular, is underrecognized as a pathogen, and detection and prevention are constrained by limited awareness by clinicians

Both hepatitis A virus (HAV) and hepatitis E virus (HEV) are highly prevalent viruses that primarily replicate in the liver and cause acute hepatic injury. Hepatitis A was originally designated as “infectious hepatitis” to distinguish it from “serum hepatitis,” which is now attributed to hepatitis B.[Krugman 1967]...

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