Hepatitis A Virus and Hepatitis E Virus: Different Viruses With Similar Stories

  • Author: Kenneth E. Sherman, MD, PhD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 5/17/18 (What's New)


  • HAV and HEV are both small RNA, nonenveloped viruses with predominantly fecal-oral transmission (Table)
    • HAV transmission may also occur through sexual activity[CDC STD] and through percutaneous exposure during the sharing of contaminated syringes between persons who inject drugs[Hutin 2000]

    • HEV can be vertically transmitted and has been detected in blood products in multiple countries, where cases of transfusion-transmitted HEV infection have been documented[Kamar 2014b

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