Hepatitis B Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Marc G. Ghany, MD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/2/18 (What's New)


  • The introduction of screening for HBsAg and anti-HBc has virtually eliminated the transmission of HBV through transfusion in the US and developed world
  • Nucleic acid testing, introduced more recently, identifies blood donors who are HBV DNA positive but do not yet have detectable HBsAg
    • This technique has further reduced the estimated risk of HBV infection from blood transfusion in the US to 1 in 830,000-2,000,000 donations[DHHS 2009]

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