Hepatitis B Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Marc G. Ghany, MD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/2/18 (What's New)


  • 5 vaccines are licensed and currently available in the US for hepatitis B vaccination[Schillie 2018a; Schillie 2018b]
  • Hepatitis B immune globulin contains anti-HBs and provides temporary protection (for ~ 3-6 months); used with hepatitis B vaccine for postexposure immunoprophylaxis
  • The CDC recommend the following groups for vaccination[CDC 2016b; Schillie 2018a]:
    • Pre- and Postvaccination Testing
        Postexposure Prophylaxis
          Hepatitis B Virus Vaccine Booster
            Hepatitis B Virus Vaccine Nonresponders

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