Hepatitis B Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Marc G. Ghany, MD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/2/18 (What's New)


    Primary Infection and Acute Hepatitis
    • Following exposure to HBV, two thirds of patients present with asymptomatic infection and one third present with acute hepatitis with jaundice; a minority (< 1%) develop fulminant hepatitis (Figure 4)[Kao 2008]
    • Acute infection is more likely to resolve in patients who present with jaundice or who are not immunosuppressed at time of infection
    • Likelihood of progression to chronicity is inversely linked to age at exposure
    Chronic Hepatitis and Its Sequelae
      Hepatitis B e Antigen–Positive Immune-Tolerant Chronic Hepatitis B
        Hepatitis B e Antigen–Positive Immune-Active Chronic Hepatitis B
          Inactive Chronic Hepatitis B
            Hepatitis B e Antigen–Negative Immune-Active Chronic Hepatitis B

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