Hepatitis B Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Marc G. Ghany, MD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/2/18 (What's New)


  • HBeAg-positive immune-tolerant chronic hepatitis B is characterized by the presence of HBeAg in serum, normal or minimally elevated ALT levels, and high HBV DNA levels (typically > 1 million IU/mL) in serum (Table 7)[Terrault 2018; Chu 1985]
    • Generally associated with acquisition of HBV infection perinatally or in early childhood
    • May last 10-30 years

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