Hepatitis B Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Marc G. Ghany, MD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/2/18 (What's New)


  • HBeAg-positive, active, chronic hepatitis B is characterized by HBeAg positivity, elevated ALT levels, and HBV DNA > 20,000 IU/mL in serum (Table 7)
    • Histology may range from mild disease to cirrhosis
    • Spontaneous HBeAg loss occurs at a rate of 10% to 20% per year

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