Hepatitis B Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Marc G. Ghany, MD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/2/18 (What's New)


  • HBeAg-negative chronic HBV infection is characterized by presence of anti-HBe, raised ALT levels, and HBV DNA > 2000 IU/mL in serum (Table 7)
    • Patients in the immune-active phases (both HBeAg positive and HBeAg negative) should be considered for treatment
    • By contrast, monitoring is recommended for those in the immune-tolerant and inactive phases

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