Hepatitis B Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Marc G. Ghany, MD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/2/18 (What's New)


  • Hepatitis B core antigen is an intracellular viral antigen present in infected hepatocytes
  • Anti-HBc, which is detectable in serum, is present in acute and chronic infection and persists after recovery
  • Among populations with a high HBV prevalence, an isolated anti-HBc positive result is likely to reflect a previous infection and loss of anti-HBs[Schillie 2018a]

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