Hepatitis B Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Marc G. Ghany, MD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/2/18 (What's New)


  • HBeAg is a secretory protein derived from the precore protein
  • HBeAg levels correlate closely with HBV DNA levels and are a marker of viral replication and infectivity[Alter 1976]
  • During acute infection, HBeAg appears shortly after the appearance of HBsAg

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