Hepatitis B Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Marc G. Ghany, MD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/2/18 (What's New)

Summary

  • Diagnosis of acute hepatitis B is based on the detection of HBsAg and anti-HBc IgM in serum (Table 9)
  • Diagnosis of chronic hepatitis B is based on the detection and persistence of HBsAg in serum for > 6 months (Table 9)
  • Patients diagnosed with chronic infection require supplemental testing to stage disease and inform treatment decision making, eg, for HBeAg and HBV DNA

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