Hepatitis B Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Marc G. Ghany, MD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/2/18 (What's New)


  • Liver biopsy is rarely necessary in patients with acute hepatitis B
  • For patients with chronic hepatitis B, liver biopsy is used to grade and stage the severity of the liver disease and to determine the need for therapy
    • Persons with moderate to severe necroinflammation, or significant fibrosis (Metavir stage ≥ F2 or Ishak stage ≥ 3) are candidates for therapy, according to international guidelines[Terrault 2018; EASL 2017; Sarin 2016]

Action required